Multi OMICs data integration
Abstract
Systems immunology is a recent research field nested under the field of systems biology that consists of measuring a variety of immunological functions as a way of discovering previously unknown phenomena as well as relationships. It is also a powerful way to get an understanding of the immune system as a whole. Due to the fact that immune cells and proteins do not function in isolation but rather continuously communicate with each other, using a multi-omics approach is helpful. Here I will present different approaches to integrate CyTOF data for multi-omics data analyses with examples stemming from systems-level immunomonitoring COVID-19 studies as well as Myalgic encephalomyelitis (ME/CFS) in order to better understand immune system regulation and function at the systems level.
Biosketch
Lucie is currently a Ph.D. candidate in Petter Brodin’s lab at Karolinksa Institutet and Science for Life Laboratory in Stockholm, Sweden. Her research mainly focuses on systems-level analyses as a means to dissect the immune system in patients with poorly-defined inflammatory conditions.
Keywords
Omics integration, Systems Immunology, Phenotypic characterization
Publications
Henrick, B. M., Rodriguez, L., Lakshmikanth, T., Pou, C., Henckel, E., Olin, A., Wang, J., Mikes, J., Tan, Z., Chen, Y., Ehrlich, A. M., Bernhardsson, A. K., Mugabo, C. H., Ambrosiani, Y., Gustafsson, A., Chew, S., Brown, H. K., Prambs, J., Bohlin, K., … Brodin, P. (2020). Bifidobacteria-mediated immune system imprinting early in life. BioRxiv, 2020.10.24.353250. https://doi.org/10.1101/2020.10.24.353250
Rodriguez, L., Pekkarinen, P. T., Lakshmikanth, T., Tan, Z., Consiglio, C. R., Pou, C., Chen, Y., Mugabo, C. H., Nguyen, N. A., Nowlan, K., Strandin, T., Levanov, L., Mikes, J., Wang, J., Kantele, A., Hepojoki, J., Vapalahti, O., Heinonen, S., Kekäläinen, E., & Brodin, P. (2020). Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2020.100078
Rodriguez, L. S. T., Pou, C., Lakshmikanth, T., Zhang, J., Mugabo, C. H., Wang, J., Mikes, J., Olin, A., Chen, Y., Rorbach, J., Juto, J.-E., Li, T. Q., Julin, P., & Brodin, P. (2020). Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance. BioRxiv, 2020.02.20.958249. https://doi.org/10.1101/2020.02.20.958249
Links
